Histiocytosis Association of Canada
Histiocytosis Association of Canada
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    • Overview
    • Langerhans Cell (LCH)
    • Juvenile Xanthogranuloma
    • Erdheim-Chester Disease
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    • Home
    • About Histiocytosis
      • Overview
      • Langerhans Cell (LCH)
      • Juvenile Xanthogranuloma
      • Erdheim-Chester Disease
      • Hemophagocytic (HLH)
      • Rosai-Dorfman
      • Diabetes Insipidus
    • Resources
      • Ask a Histio Expert
      • Pathology Webinar
      • Survivorship Webinar
      • Histiocytosis Assoc–U.S.
    • Donate
    • Find a Doctor
    • About Us
    • Contact Us
    • News
  • Home
  • About Histiocytosis
    • Overview
    • Langerhans Cell (LCH)
    • Juvenile Xanthogranuloma
    • Erdheim-Chester Disease
    • Hemophagocytic (HLH)
    • Rosai-Dorfman
    • Diabetes Insipidus
  • Resources
    • Ask a Histio Expert
    • Pathology Webinar
    • Survivorship Webinar
    • Histiocytosis Assoc–U.S.
  • Donate
  • Find a Doctor
  • About Us
  • Contact Us
  • News

About Histiocytic Disorders

 Histiocytic disorders are a group of diseases that occur when there is an over-production of white blood cells known as histiocytes that can lead to organ damage and tumor formation. 


This group of histiocytic disorders is made up of a wide variety of conditions that can affect both children and adults.  In order to reduce confusion, in 1987, the Histiocyte Society classified these disorders into three groups based on the types of histiocyte cells involved: 


(source: histio.org)

Dendritic Cell Disorders

Macrophage Cell Disorders

Macrophage Cell Disorders

 The most common disease in this group is Langerhans cell histiocytosis (LCH). Also included in this group are more rare diseases, pulmonary Langerhans cell histiocytosis (PLCH), juvenile xanthogranuloma (JXG) and Erdheim-Chester Disease (ECD). 

Macrophage Cell Disorders

Macrophage Cell Disorders

Macrophage Cell Disorders

 This group includes primarily hemophagocytic lymphohistiocytosis (HLH) and Rosai-Dorfman Disease (RDD). 

Malignant Cell Disorders

Macrophage Cell Disorders

Malignant Cell Disorders

 This group includes certain kinds of leukemia and malignant tumors. 


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