Histiocytic disorders are a group of diseases that occur when there is an over-production of white blood cells known as histiocytes that can lead to organ damage and tumor formation.
This group of histiocytic disorders is made up of a wide variety of conditions that can affect both children and adults. In order to reduce confusion, in 1987, the Histiocyte Society classified these disorders into three groups based on the types of histiocyte cells involved:
(source: histio.org)
The most common disease in this group is Langerhans cell histiocytosis (LCH). Also included in this group are more rare diseases, pulmonary Langerhans cell histiocytosis (PLCH), juvenile xanthogranuloma (JXG) and Erdheim-Chester Disease (ECD).
This group includes primarily hemophagocytic lymphohistiocytosis (HLH) and Rosai-Dorfman Disease (RDD).
This group includes certain kinds of leukemia and malignant tumors.
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